A review of LGD-4033 (Ligandrol)
LGD-4033 is thought to be the strongest SARM available to buy today. Its being made to speed recovery from hip fractures. It has a big following and unofficial use by bodybuilders and those who are attempting to improve the way they look
Ligandrol or LGD-4033 as its also known is not approved for use in humans other than by people involved in clinical trials.
What is Ligandrol?
It is a relatively new selective androgen receptor modulator (SARM) SARMs have had a lot of press recently both in the research community and from people who are wanting to improve their physique or athletic abilities.
Scientists are experimenting with how SARMs can be used to treat muscle wasting disorders and diseases like osteoporosis. Bodybuilders are touting that they are a less dangerous alternative to the use of anabolic steroids. LGD 4033 and MK2866 are probably to 2 most popular SARMs used by bodybuilders.
All SARMs bind to the androgen receptors in the muscles and bones with very high affinity and selectivity and because of this scientists think that LGD-4033 should not effect other organs such as the liver, prostate and sebaceous glands or cause suppression of your natural testosterone production. As it is not a steroid it is not possible for it to convert to estrogen and cause side effects like gynecomastia.
People who have used these drugs in trials and for bodybuilding claim that LGD-4033 is more potent than MK-2866. Some people claim that MK-2866 (Ostarine) is better than for cutting cycles. Both are preferred for their perceived muscle gains, and not causing the side effects associated with steroids.
SARM
SARMs selectively bind to the androgen receptors in muscle and bone, they activate this receptor and cause downstream changes within the cell such as uptake and utilisation of protein. As they are not chemically similar to true androgens they are not a target for the aromatase or 5 alpha-reductase enzymes which prevents their metabolism to estrogen or DHT. This is good as it eliminates the chance of the associated negative side effects.
The first generation of SARMs had a good effect on lean body mass and muscle gains and undeniably there will be a second generation that will be even more specific targeting muscle fibres and bone only. Future scientific developments in the world of drug discovery will only serve to make it easier to develop specific targets to muscle and bone.
LGD-4033 Conclusion
The anabolic activity in muscles and bones while reducing muscle loss and breakdown is un-rivelled in all the SARMs and is thought to be comparable to anabolic steroids. Ligandrol has been shown to increase lean body mass, decrease subcutaneous body fat, cause improved emotional wellbeing and improving the healing process.
